Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
Department of Pharmaceutical Sciences, Gulhane Health Science Institute, Health Science University, Ankara, Turkey.
Curr Med Chem. 2018;25(33):4020-4036. doi: 10.2174/0929867325666180322145335.
After oral administration, drug absorption from solid dosage forms depends on the release of the drug active compounds from the dosage form, the dissolution or solubilization of the drug under physiological conditions, and the permeability across the gastrointestinal tract. Dissolution testing is an essential part of designing more effective solid dosage forms in pharmaceutical industry. Moreover, dissolution testing contributes to the selection of appropriate formulation excipients for improving the dosage form efficiency. This study aims to analyze in-vitro drug dissolution testing in solid dosage forms since 2010 in order to present a comprehensive outlook of recent trends. In doing that the previous studies in the literature are summarized in the form of a table to demonstrate the apparatuses used for dissolution testing, the media in which the solid dosage form is dissolved, the method preferred for analysis from dissolution media, the conditions of analyses and the results obtained.
口服固体制剂的药物吸收取决于药物活性化合物从剂型中的释放、生理条件下药物的溶解或溶出以及穿过胃肠道的通透性。溶出度测试是制药行业设计更有效固体制剂的重要组成部分。此外，溶出度测试有助于选择适当的制剂辅料，以提高剂型效率。本研究旨在分析 2010 年以来固体制剂的体外药物溶出度测试，以呈现近期趋势的全面概况。为此，以表格形式总结了文献中的先前研究，以展示用于溶出度测试的仪器、溶解固体制剂的介质、从溶出介质中首选的分析方法、分析条件和获得的结果。
