Xu Wei, Huang Yaping, Zhang Ting, Zhao Lingyun, Fan Jun, Li Lanjuan
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, Zhejiang, China.
Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou 310058, Zhejiang, China.
J Cancer Res Ther. 2018;14(Supplement):S105-S113. doi: 10.4103/0973-1482.172110.
The association between cyclooxygenase-2 (COX-2) gene polymorphisms and hepatocellular carcinoma (HCC) has been widely reported, but the results are still controversial. To clarify the effect of COX-2 -1195G/A (rs689466), -765G/C (rs20417), and +8473T/C (rs5275) polymorphisms on HCC risk, a meta-analysis was performed.
The PubMed, Embase, Cochrane Library, Web of Science, Chinese BioMedical Literature, Wanfang, and Chinese National Knowledge Infrastructure databases were systematically searched to identify potential studies published up to October 10, 2014. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of association. A total of eight studies with 2060 HCC cases and 2610 controls for -1195G/A, six studies with 1295 cases and 2193 controls for -765G/C, and four studies with 1477 cases and 1747 controls for +8473T/C were included in this meta-analysis.
Overall, the COX-2 -1195G/A, and +8473T/C polymorphisms were both significantly associated with an increased risk of HCC (rs689466 GA + AA vs. GG: OR = 1.390, P = 0.006, 95% CI: 1.099-1.759, I = 50.7%, P = 0.048; rs5275 CC vs. TT + TC: OR = 1.484, P = 0.041, 95% CI: 1.017-2.165, I = 0.0%, P = 0.416). In the subgroup analyses stratified by ethnicity, the COX-2 -1195G/A, -765G/C, and +8473T/C were all associated with an increased HCC risk in Asian populations (rs689466 A vs. G: OR = 1.346, P = 0.001, 95% CI: 1.137-1.595, I = 0.0%, P = 0.869; rs20417 CC vs. GG + GC: OR = 3.069, P = 0.013, 95% CI: 1.265-7.447; rs5275 CC vs. TT + TC: OR = 1.626, P = 0.020, 95% CI: 1.079-2.452, I = 0.0%, P = 0.495).
Our meta-analysis suggests that -1195G/A, -765G/C, and +8473T/C in COX-2 may contribute significantly to HCC risk.
环氧化酶-2（COX-2）基因多态性与肝细胞癌（HCC）之间的关联已被广泛报道，但结果仍存在争议。为阐明COX-2 -1195G/A（rs689466）、-765G/C（rs20417）和+8473T/C（rs5275）多态性对HCC风险的影响，进行了一项荟萃分析。
系统检索PubMed、Embase、Cochrane图书馆、Web of Science、中国生物医学文献数据库、万方数据库和中国知网数据库，以识别截至2014年10月10日发表的潜在研究。计算比值比（OR）和95%置信区间（CI）以评估关联强度。本荟萃分析纳入了8项研究，共2060例HCC病例和2610例对照用于-1195G/A分析；6项研究，共1295例病例和2193例对照用于-765G/C分析；4项研究共1477例病例和1747例对照用于+8473T/C分析。
总体而言，COX-2 -1195G/A和+8473T/C多态性均与HCC风险增加显著相关（rs689466 GA + AA与GG相比：OR = 1.390，P = 0.006，95% CI：1.099 - 1.759，I² = 50.7%，P = 0.048；rs5275 CC与TT + TC相比：OR = 1.484，P = 0.041，95% CI：1.017 - 2.165，I² = 0.0%，P = 0.416）。在按种族分层的亚组分析中，COX-2 -1195G/A、-765G/C和+8473T/C在亚洲人群中均与HCC风险增加相关（rs689466 A与G相比：OR = 1.346,P = 0.001,95% CI：1.137 - 1.595，I² = 0.0%，P = 0.869；rs20417 CC与GG + GC相比：OR = 3.069，P = 0.013，95% CI：1.265 - 7.447；rs5275 CC与TT + TC相比：OR = 1.626，P = 0.020，95% CI：1.079 - 2.452，I² = 0.0%，P = 0.495）。
我们的荟萃分析表明，COX-2基因中的-1195G/A、-765G/C和+8473T/C可能对HCC风险有显著影响。
