Zhou Yong, Li Zhaohua, Ding Yinlu, Zhang Jianxin, Yang Qifeng, Wu Yuezhen
Department of General Surgery, The Second Hospital of Shandong University, Jinan 250033, P.R. China.
Department of Medical Imaging, The Second Hospital of Shandong University, Jinan 250033, P.R. China.
J Cancer Res Ther. 2018;14(Supplement):S159-S166. doi: 10.4103/0973-1482.172582.
Accumulated evidence has suggested a relationship between S100A4 protein expression and the development and progression of pancreatic cancer (PC) while its role in diagnosis and prognosis of PC still keeps inconsistent. To obtain definitive associations between S100A4 and PC, a meta-analysis was conducted.
The PubMed and Chinese National Knowledge Infrastructure databases were electronically searched to identify studies reporting an association between S100A4 protein and PC. Statistical analyses were undergone with the utilization of STATA version 12.0 software.
Nine clinical studies with a total of 545 tumor samples were included in the meta-analysis. Results revealed that increased S100A4 expression were associated with the tumor-node-metastasis stages of PC (III-IV vs. I-II: odds ratio [OR] =5.50, 95% confidence interval [95% CI] =3.13-9.67, P < 0.001). Also, compared with 1-2 histologic grade of PC samples, S100A4 protein was expressed more frequently in samples with 3-4 histologic grade (grades 1-2 vs. grades 3-4: OR = 2.57, 95% CI = 1.05-6.24, P = 0.038).
This meta-analysis showed that overexpression of S100A4 seems to be associated with tumor progression and poor prognosis of PC patients.
已有大量证据表明S100A4蛋白表达与胰腺癌（PC）的发生发展相关，但其在PC诊断和预后中的作用仍不一致。为明确S100A4与PC之间的关联，进行了一项荟萃分析。
通过电子检索PubMed和中国知网数据库，以确定报告S100A4蛋白与PC之间关联的研究。使用STATA 12.0软件进行统计分析。
荟萃分析纳入了9项临床研究，共545个肿瘤样本。结果显示，S100A4表达增加与PC的肿瘤-淋巴结-转移分期相关（III-IV期与I-II期：比值比[OR]=5.50，95%置信区间[95%CI]=3.13-9.67，P<0.001）。此外，与PC样本的1-2级组织学分级相比，S100A4蛋白在3-4级组织学分级的样本中表达更频繁（1-2级与3-4级：OR=2.57，95%CI=1.05-6.24，P=0.038）。
这项荟萃分析表明，S100A4的过表达似乎与PC患者的肿瘤进展和不良预后相关。
