衰老大鼠冠状动脉血管的代谢——一项组织化学研究。

Metabolism of coronary vasculature in senescent rats--a histochemical study.

作者信息

Amenta D, Lucreziotti R, Ramacci M T, Ricci A, Amenta F

出版信息

Arch Gerontol Geriatr. 1987 Jul;6(2):123-32. doi: 10.1016/0167-4943(87)90005-7.

Abstract

The effect of senescence on the metabolic profile of rat coronary arteries and arterioles was studied using enzyme histochemical techniques. In coronary arteries anaerobic metabolism predominates. In senescence an increase of adenosine triphosphatase (ATPase) occurred. The succinate dehydrogenase (SDH) and the respiratory chain metabolism marker NADH2-tetrazolium reductase (NADHD) showed an age-related decrease. Lactate dehydrogenase was unchanged. In the coronary arterioles, on the contrary, aerobic metabolism dominates. In senescence a significant decrease of NADHD and a moderate reduction of SDH and ATPase was observed. L-Carnitine administration significantly stimulated some enzymatic activities related to aerobic metabolism primarily at the arteriolar level.

摘要

采用酶组织化学技术研究了衰老对大鼠冠状动脉和小动脉代谢谱的影响。在冠状动脉中，无氧代谢占主导。在衰老过程中，三磷酸腺苷酶（ATPase）增加。琥珀酸脱氢酶（SDH）和呼吸链代谢标志物NADH2-四氮唑还原酶（NADHD）呈现与年龄相关的下降。乳酸脱氢酶没有变化。相反，在冠状小动脉中，有氧代谢占主导。在衰老过程中，观察到NADHD显著下降，SDH和ATPase适度降低。左旋肉碱给药主要在小动脉水平显著刺激了一些与有氧代谢相关的酶活性。