Donaldson M C, Matthews E T, Hadjimichael J, Rickles F R
Arch Surg. 1987 Aug;122(8):897-900. doi: 10.1001/archsurg.1987.01400200047007.
Levels of the platelet degranulation product beta-thromboglobulin (BTG) and the fibrinogen degradation product fibrinopeptide A (FPA) were measured in 26 asymptomatic subjects (group 1), 17 patients with peripheral vascular disease (PVD) (group 2), and 12 patients with PVD and bypass grafts (group 3). Mean BTG and FPA levels were elevated in both groups 2 and 3, indicating increased thrombotic activity in patients with PVD. Results of serial BTG and FPA assays in group 3 patients suggested a trend downward. These markers may be useful for estimating disease severity and prognosis, extent of graft healing and patency, and efficacy of therapeutic intervention.
在26名无症状受试者（第1组）、17名外周血管疾病（PVD）患者（第2组）和12名患有PVD并接受搭桥手术的患者（第3组）中，检测了血小板脱颗粒产物β-血小板球蛋白（BTG）和纤维蛋白原降解产物纤维蛋白肽A（FPA）的水平。第2组和第3组的平均BTG和FPA水平均升高，表明PVD患者的血栓形成活性增加。第3组患者的系列BTG和FPA检测结果呈下降趋势。这些标志物可能有助于评估疾病的严重程度和预后、移植物愈合和通畅程度以及治疗干预的效果。
