Department of Pediatrics, Division of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.
Department of Pediatrics, Division of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.
J Cyst Fibros. 2018 Nov;17(6):783-790. doi: 10.1016/j.jcf.2018.03.008. Epub 2018 Mar 23.
To characterize glucose patterns with continuous glucose monitoring (CGM) in cystic fibrosis (CF) and assess relationships between CGM and clinical outcomes.
110 CF youth and healthy controls (HC), 10-18 years, wore CGM up to 7 days. Correlations between CGM and lung function and BMI z-score change over the prior year were determined.
Multiple CGM measures were higher in CF Normal Glycemic (CFNG) youth versus HC (peak glucose, excursions >140 mg/dl/day, %time > 140 mg/dl, standard deviation (SD) and mean amplitude of glycemic excursions (MAGE)). Hypoglycemia was no different among groups. In CF, decline in FEV1% and FVC% correlated with maximum CGM glucose, excursions >200 mg/dl/day, SD, and MAGE.
CFNG youth have higher glucoses and glucose variability than HC on CGM. Higher and more variable glucoses correlate with lung function decline. Whether earlier treatment of CGM abnormalities improves lung function in CF requires further study.
使用连续血糖监测（CGM）描绘囊性纤维化（CF）患者的血糖模式，并评估 CGM 与临床结局之间的关系。
110 名 CF 青少年和健康对照者（HC），年龄 10-18 岁，佩戴 CGM 长达 7 天。确定 CGM 与肺功能和前一年 BMI z 分数变化之间的相关性。
与 HC 相比，CF 正常血糖（CFNG）青少年的多项 CGM 指标更高（峰值血糖、>140mg/dl/天的血糖波动、>140mg/dl 的时间百分比、标准差和血糖波动幅度的平均幅度（MAGE））。各组之间的低血糖无差异。在 CF 中，FEV1%和 FVC%的下降与最大 CGM 血糖、>200mg/dl/天的血糖波动、SD 和 MAGE 相关。
与 HC 相比，CFNG 青少年的 CGM 血糖水平更高且血糖变异性更大。更高和更可变的血糖与肺功能下降相关。早期治疗 CGM 异常是否能改善 CF 患者的肺功能，需要进一步研究。
