Noda Takahiro, Takahashi Hirokazu
Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Neurosci Res. 2019 Apr;141:52-62. doi: 10.1016/j.neures.2018.03.007. Epub 2018 Mar 23.
Perceptual organization of sound sequences into separate sound sources or streams is called auditory stream segregation. Neural substrates for this process in both the spectral and temporal domains remain to be elucidated. Despite abundant knowledge about their auditory physiology, behavioral evidence for auditory streaming in rodents is still limited. We provided behavioral evidence for auditory streaming in the go/no-go discrimination task, but not in the two-alternative choice task. In the go/no-go discrimination phase, rats were able to discriminate different rhythms corresponding to segregated or integrated tone sequences in both short inter-tone interval (ITI) and long ITI conditions. Nevertheless, performance was poorer in the long ITI group. In probe testing, which assessed the ability to discriminate one of the segregated tone sequences from ABA- tone sequences, the detection rate increased with the difference in frequency (ΔF) for short (100 ms), but not long (200 ms) ITIs. Our results indicate that auditory streaming in rats on both the spectral and temporal features in the ABA- tone paradigm is qualitatively analogous to that observed in human psychophysics studies. This suggests that rodents are a valuable model for investigating the neural substrates of auditory streaming.
将声音序列感知组织成单独的声源或声流的过程称为听觉流分离。该过程在频谱和时间域中的神经基质仍有待阐明。尽管对啮齿动物的听觉生理学有丰富的了解，但关于啮齿动物听觉流的行为证据仍然有限。我们在“是/否”辨别任务中提供了听觉流的行为证据，但在二选一选择任务中没有。在“是/否”辨别阶段，大鼠能够在短音间间隔（ITI）和长ITI条件下辨别与分离或整合的音调序列相对应的不同节奏。然而，长ITI组的表现较差。在探测测试中，该测试评估了从ABA音调序列中辨别出分离的音调序列之一的能力，对于短（100毫秒）而不是长（200毫秒）ITI，检测率随频率差（ΔF）增加。我们的结果表明，在ABA音调范式中，大鼠在频谱和时间特征上的听觉流在质量上类似于人类心理物理学研究中观察到的情况。这表明啮齿动物是研究听觉流神经基质的有价值模型。
