Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.
Department of Aerospace Medicine, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.
Ageing Res Rev. 2018 Jul;44:8-21. doi: 10.1016/j.arr.2018.03.004. Epub 2018 Mar 23.
Recently, growing evidence has demonstrated that peroxisome proliferator activated receptor γ (PPARγ) coactivator-1α (PGC-1α) is a superior transcriptional regulator that acts via controlling the expression of anti-oxidant enzymes and uncoupling proteins and inducing mitochondrial biogenesis, which plays a beneficial part in the central nervous system (CNS). Given the significance of PGC-1α, we summarize the current literature on the molecular mechanisms and roles of PGC-1α in the CNS. Thus, in this review, we first briefly introduce the basic characteristics regarding PGC-1α. We then depict some of its important cerebral functions and discuss upstream modulators, partners, and downstream effectors of the PGC-1α signaling pathway. Finally, we highlight recent progress in research on the involvement of PGC-1α in certain major neurodegenerative disorders (NDDs), including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Collectively, the data presented here may be useful for supporting the future potential of PGC-1α as a therapeutic target.
最近，越来越多的证据表明过氧化物酶体增殖物激活受体γ（PPARγ）共激活因子-1α（PGC-1α）是一种优越的转录调节因子，通过控制抗氧化酶和解偶联蛋白的表达以及诱导线粒体生物发生来发挥作用，这对中枢神经系统（CNS）有益。鉴于 PGC-1α 的重要性，我们总结了目前关于 PGC-1α 在中枢神经系统中的分子机制和作用的文献。因此，在这篇综述中，我们首先简要介绍 PGC-1α 的基本特征。然后，我们描述了它在大脑中的一些重要功能，并讨论了 PGC-1α 信号通路的上游调节剂、伴侣和下游效应物。最后，我们强调了 PGC-1α 参与某些主要神经退行性疾病（NDDs）的研究的最新进展，包括阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩侧索硬化症。总之，这里呈现的数据可能有助于支持 PGC-1α 作为治疗靶点的未来潜力。
