Viera-Molina M, Guerra-Martín M D
Universidad de Sevilla.
An Sist Sanit Navar. 2018 Apr 30;41(1):107-116. doi: 10.23938/ASSN.0254.
There are a high number of people affected by infertility who require assisted reproduction techniques. For this reason the aim of this review was to analyze the effectiveness of the interventions carried out using these techniques. A systematic peer review was performed on twelve databases. Inclusion criteria were: randomized clinical trials, published between 2011 and 2016, and with a score greater than two on the Jadad scale. The pharmacological interventions that proved effective were the administration of hormones, intrauterine human chorionic gonadotropin, gonadotrophin and dehydroepiandrosterone, and metformin. An effective surgical intervention, endometrial scratching, was identified. No effective non-pharmacological interventions were found. Assisted reproduction techniques show heterogeneity in both the interventions included and effectiveness criteria (pregnancy rate, live birth rate or implantation rate), which makes a unification of criteria necessary.
有大量受不孕症影响的人需要辅助生殖技术。因此,本综述的目的是分析使用这些技术进行干预的有效性。对12个数据库进行了系统的同行评审。纳入标准为:2011年至2016年间发表的随机临床试验,且在雅达量表上得分大于2。被证明有效的药物干预措施包括激素给药、宫腔内注射人绒毛膜促性腺激素、促性腺激素和脱氢表雄酮,以及二甲双胍。确定了一种有效的手术干预措施,即子宫内膜搔刮术。未发现有效的非药物干预措施。辅助生殖技术在纳入的干预措施和有效性标准(妊娠率、活产率或着床率)方面均表现出异质性,这使得统一标准变得必要。