Martinez C, Pereira P, De la Hera A, Toribio M, Marcos M R, Marquez C, Coutinho A
Centro de Biologia Molecular, CSIC, Universidad Autonoma, Madrid, Spain.
Eur J Immunol. 1987 Sep;17(9):1391-4. doi: 10.1002/eji.1830170928.
The monoclonal antibody F6(51), directed to an idiotope of MOPC 460-like anti-1,4,6-trinitrophenl (TNP) antibodies produced in IgHa mouse strains, identifies in helper T cells from C57BL/6 (IgHb) mice with (4-hydroxy-3-nitrophenyl)acetyl (NP)-self specificity, a clonotypic determinant functionally and biochemically associated with the specific T cell receptor. The expression of this antibody-related T cell clonotype in C57BL/6 mice, although "recurrent", is independent of network selection, as shown by its presence in B mice suppressed from birth with anti-mu antibodies, and in IgH-congenic mouse strains. These results indicate aleatory cross-reactivity between T cell receptors and antibodies and command caution in network interpretations for "idiotype sharing".
单克隆抗体F6(51)针对在IgHa小鼠品系中产生的MOPC 460样抗-1,4,6-三硝基苯（TNP）抗体的独特型表位，在具有（4-羟基-3-硝基苯基）乙酰基（NP）自身特异性的C57BL/6（IgHb）小鼠的辅助性T细胞中识别出一种与特异性T细胞受体在功能和生化上相关的克隆型决定簇。这种与抗体相关的T细胞克隆型在C57BL/6小鼠中的表达虽然“反复出现”，但与网络选择无关，这一点已通过其在出生时就用抗μ抗体抑制的B小鼠以及IgH同基因小鼠品系中的存在得到证明。这些结果表明T细胞受体和抗体之间存在偶然的交叉反应性，并要求在对“独特型共享”的网络解释中保持谨慎。
