LY165163和8-羟基二苯丙氨酸对海兔的5-羟色胺反应性肌肉具有激动作用。
LY165163 and 8-OH-DPAT have agonist effects on a serotonin responsive muscle of Aplysia.
作者信息
Ram J L, Kreiman M A, Gole D
机构信息
Department of Physiology, Wayne State University, Detroit, MI 48201.
出版信息
Eur J Pharmacol. 1987 Jul 9;139(2):247-50. doi: 10.1016/0014-2999(87)90259-7.
Serotonin enhances acetylcholine-elicited contractions of buccal muscle E1 of Aplysia. To characterize the serotonin receptor, actions of ligands of specific serotonin receptor subtypes were examined. Ketanserin, an antagonist at 5-HT2 receptors, had little effect. Two 5-HT1A ligands, LY165163 and 8-OH-DPAT, mimicked the effect of serotonin, although with slower kinetics. This suggests that the peripheral serotonin receptor in Aplysia more closely resembles 5-HT1 than 5-HT2 receptors.
血清素可增强海兔颊肌E1的乙酰胆碱引发的收缩。为了表征血清素受体，研究了特定血清素受体亚型配体的作用。5-HT2受体拮抗剂酮色林几乎没有作用。两种5-HT1A配体LY165163和8-OH-DPAT模拟了血清素的作用，尽管动力学较慢。这表明海兔外周血清素受体与5-HT1受体的相似性高于5-HT2受体。
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