Department of Psychiatry & Laboratory of Psychiatric Research (ULB 266), Cliniques universitaires de Bruxelles, Université Libre de Bruxelles (ULB), Bruxelles, Belgium.
PLoS One. 2018 Mar 27;13(3):e0193619. doi: 10.1371/journal.pone.0193619. eCollection 2018.
The relationships between anhedonia and suicidal ideation or suicide attempts were explored in a large sample of physicians using the interpersonal psychological theory of suicide. We tested two hypotheses: firstly, that there is a significant relationship between anhedonia and suicidality and, secondly, that anhedonia could mediate the relationships between suicidal ideation or suicide attempts and thwarted belongingness or perceived burdensomeness.
In a cross-sectional study, 557 physicians filled out several questionnaires measuring suicide risk, depression, using the abridged version of the Beck Depression Inventory (BDI-13), and demographic and job-related information. Ratings of anhedonia, perceived burdensomeness and thwarted belongingness were then extracted from the BDI-13 and the other questionnaires.
Significant relationships were found between anhedonia and suicidal ideation or suicide attempts, even when significant variables or covariates were taken into account and, in particular, depressive symptoms. Mediation analyses showed significant partial or complete mediations, where anhedonia mediated the relationships between suicidal ideation (lifetime or recent) and perceived burdensomeness or thwarted belongingness. For suicide attempts, complete mediation was found only between anhedonia and thwarted belongingness. When the different components of anhedonia were taken into account, dissatisfaction-not the loss of interest or work inhibition-had significant relationships with suicidal ideation, whereas work inhibition had significant relationships with suicide attempts.
Anhedonia and its component of dissatisfaction could be a risk factor for suicidal ideation and could mediate the relationship between suicidal ideation and perceived burdensomeness or thwarted belongingness in physicians. Dissatisfaction, in particular in the workplace, may be explored as a strong predictor of suicidal ideation in physicians.
本研究采用人际心理理论对自杀的理论模型,探讨了快感缺失与自杀意念或自杀未遂之间的关系。我们检验了两个假设:第一,快感缺失与自杀意念或自杀未遂之间存在显著关系;第二,快感缺失可以在自杀意念或自杀未遂与归属感缺失或无用感之间的关系中起中介作用。
在横断面研究中,557 名医生填写了几份问卷,包括自杀风险、使用贝克抑郁量表(BDI-13)的抑郁程度、人口统计学和工作相关信息。然后从 BDI-13 和其他问卷中提取快感缺失、无用感和归属感缺失的评分。
即使考虑了重要的变量或协变量,尤其是抑郁症状,仍发现快感缺失与自杀意念或自杀未遂之间存在显著关系。中介分析显示,快感缺失对自杀意念(终生或近期)与无用感或归属感缺失之间的关系具有显著的部分或完全中介作用。对于自杀未遂,快感缺失仅与归属感缺失之间存在完全中介作用。当考虑快感缺失的不同组成部分时,不满意而不是兴趣丧失或工作抑制与自杀意念之间存在显著关系,而工作抑制与自杀未遂之间存在显著关系。
快感缺失及其不满意成分可能是自杀意念的一个风险因素,并可以在医生的自杀意念与无用感或归属感缺失之间的关系中起中介作用。特别是在工作场所的不满情绪,可能是医生自杀意念的一个强有力的预测因素。