Lam S, Margo C E, Beck R, Pusateri T J, Pascucci S
Section of Ophthalmology, Veterans Administration Hospital, Tampa, Florida.
J Clin Neuroophthalmol. 1987 Sep;7(3):135-8.
A 76-year-old man developed a cavernous sinus syndrome as the initial manifestation of multiple myeloma. Although clinically the patient had stage IA disease, which is typically associated with a favorable response to therapy, his disease was rapidly fatal. This case emphasizes a weakness of the traditional staging system because it does not take into account certain clinical and histopathologic aspects of myeloma relevant to extramedullary plasmacytomas. Since disorders of ocular motility are more likely to be associated with extramedullary myeloma than myeloma confined to the marrow, clinicians need to be aware of the limitations in the clinical staging system and the potential problems associated with anaplastic plasmacytomas.
一名76岁男性以海绵窦综合征作为多发性骨髓瘤的首发表现。尽管临床上该患者为IA期疾病，通常对治疗反应良好，但他的病情迅速恶化并导致死亡。该病例凸显了传统分期系统的一个弱点，即它没有考虑到骨髓瘤与髓外浆细胞瘤相关的某些临床和组织病理学方面。由于眼球运动障碍与髓外骨髓瘤的关联比局限于骨髓的骨髓瘤更为常见，临床医生需要意识到临床分期系统的局限性以及与间变性浆细胞瘤相关的潜在问题。
