Vinnikova M G, Makarevich Ia A
Kardiologiia. 1987 Jul;27(7):56-9.
Combined assessment of some parameters related to hemostasis and blood plasminogen-plasmin and kinin systems and their inhibitors was carried out in 150 patients with stable angina and postinfarction cardiosclerosis during rationed exercise (bicycle ergometry). Patients with low stress tolerance showed considerably activated kallikrein-kinin system, depressed total fibrinolytic activity, elevated trypsin and enhanced platelet adhesive properties, while their inhibitor activities were reduced. Postmyocardial infarction patients showed a more dramatic increase in free kinins, coupled with depressed inhibitor proteinases and kininase activities, and a slight increment in fibrinolytic activity, as compared to patients having to history of myocardial infarction. The magnitude of free kinins and trypsin rise and kininase fall increases with age in these patients.
对150例稳定型心绞痛和心肌梗死后心脏硬化患者在定量运动(自行车测力计测试)期间进行了与止血、血浆纤溶酶原 - 纤溶和激肽系统及其抑制剂相关的一些参数的联合评估。应激耐受性低的患者显示激肽释放酶 - 激肽系统显著激活,总纤溶活性降低,胰蛋白酶升高,血小板黏附特性增强,而其抑制剂活性降低。与无心肌梗死病史的患者相比,心肌梗死后患者的游离激肽显著增加,同时抑制蛋白酶和激肽酶活性降低,纤溶活性略有增加。这些患者中游离激肽和胰蛋白酶升高以及激肽酶降低的幅度随年龄增加。