Leonard J C, Merz T
Medical Department, Brookhaven National Laboratory, Upton, NY 11973.
Mutat Res. 1987 Oct;180(2):223-30. doi: 10.1016/0027-5107(87)90218-1.
We have compared the frequencies of chromosomal aberrations in skin fibroblasts from persons with Down's syndrome (trisomy 21) with those from normal diploid controls exposed to 60Co gamma-radiation in vitro. No difference between the chromosomal radiosensitivities of the two groups was observed, nor did the two groups differ in the background frequency of spontaneous aberrations. These data support the hypothesis that the increased in vitro chromosomal radiosensitivity of lymphocytes reported to be associated with trisomy 21 is not typical of all tissues.
我们比较了唐氏综合征（21三体）患者皮肤成纤维细胞与体外暴露于60Coγ射线的正常二倍体对照者皮肤成纤维细胞的染色体畸变频率。未观察到两组染色体放射敏感性之间存在差异，两组的自发畸变背景频率也无差异。这些数据支持了以下假说，即据报道与21三体相关的淋巴细胞体外染色体放射敏感性增加并非所有组织的典型特征。
