唐氏综合征、肥胖症、阿尔茨海默病与癌症：简要综述及假说
Down Syndrome, Obesity, Alzheimer's Disease, and Cancer: A Brief Review and Hypothesis.
作者信息
Nixon Daniel W
机构信息
Cancer Treatment Centers of America, Southeastern Regional Medical Center, Newnan, GA 30265, USA.
Morehouse School of Medicine, Atlanta, GA 30310, USA.
出版信息
Brain Sci. 2018 Mar 24;8(4):53. doi: 10.3390/brainsci8040053.
Abstract
Down syndrome (trisomy 21), a complex mix of physical, mental, and biochemical issues, includes an increased risk of Alzheimer's disease and childhood leukemia, a decreased risk of other tumors, and a high frequency of overweight/obesity. Certain features related to the third copy of chromosome 21 (which carries the APP gene and several anti-angiogenesis genes) create an environment favorable for Alzheimer's disease and unfavorable for cancer. This environment may be enhanced by two bioactive compounds from fat cells, leptin, and adiponectin. This paper outlines these fat-related disease mechanisms and suggests new avenues of research to reduce disease risk in Down syndrome.
摘要
唐氏综合征（21三体综合征）是一种身体、智力和生化问题的复杂组合，包括患阿尔茨海默病和儿童白血病的风险增加、患其他肿瘤的风险降低以及超重/肥胖的高发生率。与21号染色体的第三个拷贝（携带APP基因和几个抗血管生成基因）相关的某些特征为阿尔茨海默病创造了有利环境，而对癌症不利。来自脂肪细胞的两种生物活性化合物瘦素和脂联素可能会加剧这种环境。本文概述了这些与脂肪相关的疾病机制，并提出了降低唐氏综合征疾病风险的新研究途径。
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The Inverse Relationship Between Cancer and Alzheimer's Disease: A Possible Mechanism.癌症与阿尔茨海默病之间的反向关系：一种可能的机制。
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