Institute for Liver and Digestive Health, Division of Medicine, University College London, Royal Free Hospital, Rowland Hill Street, NW3 2PF, London, UK.
Gynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, London, UK.
BMC Public Health. 2018 Mar 27;18(1):409. doi: 10.1186/s12889-018-5308-x.
We investigated the association between self-reported skirt size (SS) and change in SS, and incidence of chronic liver disease (CLD) in a prospective cohort study of women recruited to the UKCTOCS trial.
Women recruited to UKCTOCS in England without documented CLD self-reported their current UK SS during trial participation and were asked to recall their SS when aged in 20s (via completion of a questionnaire 3-5 years after recruitment). Participants were followed up via electronic health record linkage and hazard ratios (HR) calculated for incident liver-related events (LRE).
Three hundred twenty-two (0.3%) of 94,124 women experienced a first LRE. Compared to SS ≤ 16, rates of LRE were higher in the SS ≥ 18 groups (both when aged in 20s and at questionnaire completion). Event rates were higher if there was no change in SS or an increase in SS, compared to a decrease in SS. In the models adjusted for potential confounders, HRs for LRE were higher in the groups of women reporting SS ≥ 18 both when aged in 20s (HR = 1.39 (95% CI; 0.87-2.23)) and at questionnaire completion (HR = 1.37 (95% CI; 1.07-1.75)). Compared to a decrease in SS, HRs were higher in the no change (HR = 1.78 (95% CI; 0.95-3.34)) and increase (HR = 1.80 (95% CI; 1.01-3.21)) groups.
CLD is associated with high SS and an increase in SS over time. These data suggest SS can be used in simple public health messages about communicating the risk of liver disease.
UKCTOCS is registered as an International Standard Randomised Controlled Trial, number ISRCTN22488978 . Registered 06/04/2000.
我们在一项针对英国 CTOCS 试验招募的女性的前瞻性队列研究中，调查了自我报告的裙子尺码（SS）和 SS 变化与慢性肝病（CLD）发病率之间的关系。
在英国 CTOCS 试验中招募的没有记录 CLD 的女性在试验期间报告了她们当前的英国 SS，并被要求回忆她们 20 多岁时的 SS（通过在招募后 3-5 年内完成问卷）。通过电子健康记录链接对参与者进行随访，并计算出与肝脏相关事件（LRE）相关的发病率比（HR）。
在 94124 名女性中，有 322 名（0.3%）发生了首次 LRE。与 SS≤16 相比，SS≥18 组的 LRE 发生率更高（无论是在 20 多岁时还是在完成问卷时）。与 SS 减少相比，SS 没有变化或增加的情况下，LRE 发生率更高。在调整了潜在混杂因素的模型中，当女性报告 SS≥18 时，无论是在 20 多岁时（HR=1.39（95%CI：0.87-2.23））还是在完成问卷时（HR=1.37（95%CI：1.07-1.75）），LRE 的 HR 更高。与 SS 减少相比，SS 不变（HR=1.78（95%CI：0.95-3.34））和增加（HR=1.80（95%CI：1.01-3.21））组的 HR 更高。
CLD 与高 SS 和 SS 随时间的增加有关。这些数据表明，SS 可以用于关于传达肝病风险的简单公共卫生信息。
英国 CTOCS 作为一项国际标准随机对照试验进行注册，编号为 ISRCTN22488978。于 2000 年 4 月 6 日注册。
