层粘连蛋白表达作为口腔白斑病异型增生的预测标志物。

Podoplanin expression as a predictive marker of dysplasia in oral leukoplakia.

机构信息

Department of Biomedical and Neuromotor Sciences (Head: Prof Lucio Montebugnoli), Section of Oral Sciences, University of Bologna, Italy.

出版信息

J Craniomaxillofac Surg. 2018 May;46(5):759-764. doi: 10.1016/j.jcms.2018.02.016. Epub 2018 Mar 9.

DOI:10.1016/j.jcms.2018.02.016

PMID:29588189

Abstract

PURPOSE

Recent studies have emphasized the role of podoplanin in oral lesions at risk of malignant transformation. We investigated a group of oral leukoplakias (OLs) to determine a possible relation between altered podoplanin expression and dysplasia, and to compare the results with those obtained by other, widely used biomarkers.

MATERIALS AND METHODS

The population consisted of 40 consecutive patients with a clinical and histological diagnosis of OL. Thirty-two OLs did not show dysplasia, whereas eight lesions presented with dysplasia. Immunohistochemical expression of podoplanin, p53 and Ki67 was analyzed in all samples.

RESULTS

All three biomarkers were positive in seven of eight dysplastic OLs. Among the 32 OLs without dysplasia, Ki67 and p53 showed positive values in 21 and 10 samples respectively, whereas podoplanin was positive in only one case. Multiple logistic regression showed that podoplanin was the most powerful variable (Chi square 9.77; p < .01) statistically related to the presence of dysplasia. In addition, podoplanin showed a higher specificity value (96.87%) than Ki67 (34.37%) and p53 (68.75%).

CONCLUSION

Podoplanin seems to be a reliable means of discriminating lesions with epithelial dysplasia and could be introduced in routine practice as a marker to discriminate OLs at risk of developing cancer.

摘要

目的

最近的研究强调了足突蛋白在有恶性转化风险的口腔病变中的作用。我们研究了一组口腔白斑（OL），以确定改变的足突蛋白表达与发育不良之间的可能关系，并将结果与其他广泛使用的生物标志物的结果进行比较。

材料和方法

该人群由 40 名连续的 OL 患者组成，具有临床和组织学诊断。32 例 OL 无发育不良，而 8 例病变有发育不良。对所有样本进行足突蛋白、p53 和 Ki67 的免疫组织化学表达分析。

结果

在 8 例发育不良的 OL 中，三种生物标志物均为阳性。在 32 例无发育不良的 OL 中，Ki67 和 p53 分别在 21 例和 10 例中呈阳性，而足突蛋白仅在 1 例中呈阳性。多元逻辑回归显示，足突蛋白是与发育不良存在最相关的最有力变量（卡方 9.77；p<.01）。此外，与 Ki67（34.37%）和 p53（68.75%）相比，足突蛋白的特异性值更高（96.87%）。