[铁过载及螯合治疗在重型地中海贫血合并耶尔森菌感染中的作用]
[Roles of iron overload and chelating treatment in Yersinia infectious complicated by major thalassemia].
作者信息
François P, Bachelot C, Andrini P, Bost M
机构信息
Service de Médecine infantile, Centre hospitalier régional et universitaire de Grenoble, La Tronche.
出版信息
Presse Med. 1987 Oct 3;16(32):1574-6.
A study of 3 personal and 32 published cases showed that Yersinia septicaemia in subjects under 21 presents as digestive disorders with fever and occurs in one half of the cases in thalassaemia patients. Among the factors which may be blamed for this predisposition the most important are excessive tissue iron levels and treatment with chelating agents. Iron overload is present in 70% of patients with Yersinia septicaemia. The risk of infection in such subjects requires appropriate therapeutic measures.
一项针对3例个人病例和32例已发表病例的研究表明，21岁以下人群的耶尔森氏菌败血症表现为伴有发热的消化系统紊乱，且在地中海贫血患者中，有一半的病例会出现这种情况。在可能导致这种易感性的因素中，最重要的是组织铁水平过高和使用螯合剂进行治疗。70%的耶尔森氏菌败血症患者存在铁过载。这类患者的感染风险需要采取适当的治疗措施。
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