心血管药物治疗领域的近期重大进展。
Recent major advances in cardiovascular pharmacotherapy.
作者信息
Milner James, Cunha Andreia, Gamboa-Cruz Carlota, Reis Julie, Campos Márcia, António Natália
机构信息
Cardiology Department, Coimbra Hospital and Universitary Centre, Coimbra, Portugal.
Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
出版信息
Eur J Clin Pharmacol. 2018 Jul;74(7):853-862. doi: 10.1007/s00228-018-2453-1. Epub 2018 Mar 27.
The field of cardiovascular pharmacotherapy remains extremely active. The aim of this review is to summarize the recent major advances in cardiovascular pharmacotherapy, with a focus on (1) the new approved drug for treatment of heart failure with reduced ejection fraction-sacubitril/valsartan; (2) proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors; (3) the novel reversal agents for non-vitamin K oral anticoagulants (NOACs); and finally, (4) new evidence on pharmacological treatment of coronary artery disease.
心血管药物治疗领域仍然极为活跃。本综述的目的是总结心血管药物治疗方面的近期主要进展，重点关注：（1）用于治疗射血分数降低的心力衰竭的新批准药物——沙库巴曲缬沙坦；（2）前蛋白转化酶枯草溶菌素/克新9型（PCSK9）抑制剂；（3）新型非维生素K口服抗凝药（NOACs）的逆转剂；最后，（4）冠状动脉疾病药物治疗的新证据。
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