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风湿性多肌痛的观点与未满足的需求。为风湿性多肌痛新治疗方案的开发提供基本框架。

Perspectives and unmet needs in polymyalgia rheumatica. Providing the fundamental framework for the development of new treatment regimes in polymyalgia rheumatica.

作者信息

Nielsen B D, Dasgupta B

机构信息

Department of Rheumatology and Department of Clinical Medicine, Aarhus University Hospital.

出版信息

Reumatismo. 2018 Mar 27;70(1):1-9. doi: 10.4081/reumatismo.2018.1070.

Abstract

Polymyalgia rheumatica is effectively treated with glucocorticoids. However, glucocorticoid treatment can cause numerous and potentially serious side effects. Therefore, lowest effective dose and shortest duration to control disease is aimed for and glucocorticoid-sparing treatments are needed. Nevertheless, development of treatment regimens in PMR has been hampered by the lack of reliable classification criteria and evidence-based outcome measures. In this editorial, we discuss the need for valid classification criteria in PMR, the strengths and limitations of the ACR/EULAR 2012 provisional classification criteria for PMR and the need of validation and possible refining of the criteria.

摘要

风湿性多肌痛用糖皮质激素治疗有效。然而,糖皮质激素治疗可引起众多且可能严重的副作用。因此,目标是使用能控制疾病的最低有效剂量和最短疗程,并需要采用糖皮质激素节省疗法。尽管如此,可靠的分类标准和基于证据的疗效评估指标的缺乏阻碍了风湿性多肌痛治疗方案的发展。在这篇社论中,我们讨论了风湿性多肌痛有效分类标准的必要性、美国风湿病学会/欧洲抗风湿病联盟2012年风湿性多肌痛临时分类标准的优点和局限性,以及该标准验证和可能改进的必要性。

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