Pannier B, Asmar R, Laurent S, London G, Safar M
Centre de Diagnostic, Hôpital Broussais, Paris.
Arch Mal Coeur Vaiss. 1987 Jun;80(6):879-82.
Forearm venous tone (FVT), carotido-femoral pulse wave velocity (PWV), and left ventricular end diastolic diameter (LVD), left ventricular posterior wall thickness (LVPWT), myocardiac mass (MM), measured by echography were evaluated on 25 subjects with sustained essential hypertension and 30 normotensive subjects with same age and same sex. For the overall population, FVT is positively correlated with LVD (r = 0.45, p less than 0.001), with LVPWT (r = 0.37, p less than 0.01) and with MM (r = 0.55, p less than 0.001). PWV is not correlated with LVD but is positively correlated with LVPWT (r = 0.48, p less than 0.001) and with MM (r = 0.40, p less than 0.01). Stroke volume is positively correlated with FVT (r = 0.42, p less than 0.01), but not with PWV. This study shows that in a population of normals and sustained essential hypertensive subjects: i) indexes of venous compliance are correlated with myocardial thickness, myocardiac mass, left ventricular diameter and stroke volume, while ii) indexes of arterial compliance are only correlated with myocardial thickness. Thus, the modifications of arterial and venous compliance observed in sustained essential hypertension influence cardiac structure and function.
对25名持续性原发性高血压患者和30名年龄及性别匹配的血压正常者,评估了超声测量的前臂静脉张力(FVT)、颈股脉搏波速度(PWV)、左心室舒张末期内径(LVD)、左心室后壁厚度(LVPWT)及心肌质量(MM)。对于总体人群,FVT与LVD呈正相关(r = 0.45,p < 0.001),与LVPWT呈正相关(r = 0.37,p < 0.01),与MM呈正相关(r = 0.55,p < 0.001)。PWV与LVD无相关性,但与LVPWT呈正相关(r = 0.48,p < 0.001),与MM呈正相关(r = 0.40,p < 0.01)。每搏输出量与FVT呈正相关(r = 0.42,p < 0.01),但与PWV无相关性。本研究表明,在正常人和持续性原发性高血压患者群体中:i)静脉顺应性指标与心肌厚度、心肌质量、左心室直径及每搏输出量相关,而ii)动脉顺应性指标仅与心肌厚度相关。因此,在持续性原发性高血压中观察到的动静脉顺应性改变会影响心脏结构和功能。