Seidenberg J, Masters I B, Hudson I, Olinsky A, Phelan P D
Professional Department of Thoracic Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.
Aust Paediatr J. 1987 Jun;23(3):169-72. doi: 10.1111/j.1440-1754.1987.tb00238.x.
The effect of nebulized ipratropium bromide in 14 infants (mean age: 20 weeks, range: 4-41) with acute respiratory syncytial virus bronchiolitis was examined. A modified rapid chest compression technique was used to obtain partial expiratory flow-volume curves and maximum flow at functional residual capacity. Passive respiratory mechanics were assessed by brief occlusion at end inspiration. Thoracic gas volume was measured in a body plethysmograph. No significant difference was found in forced and passive respiratory mechanics pre- and post-ipratropium bromide. No subgroups could be identified. These results do not support the use of ipratropium bromide in acute viral bronchiolitis.
