FOXP3 的可变剪接：好处与坏处。
Alternative Splicing of FOXP3-Virtue and Vice.
机构信息
Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Cardiovascular Medicine Unit, Department of Medicine, Karolinska Insititutet, Stockholm, Sweden.
出版信息
Front Immunol. 2018 Mar 13;9:530. doi: 10.3389/fimmu.2018.00530. eCollection 2018.
FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed.
FOXP3 是 CD4+ CD25+ 调节性 T 细胞的谱系定义转录因子。尽管其调节、相互作用和功能的许多方面在物种间是保守的，但 FOXP3 的剪接异构体仅在人类细胞中表达。本文综述了 FOXP3 剪接的最新知识以及 FOXP3 异构体在健康和疾病中的特定功能。讨论了未来研究的展望以及操纵 FOXP3 剪接的治疗潜力。
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