LeMaistre A, Bracey A, Katz A, Wu A H
Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston 77030.
Clin Chem. 1987 Oct;33(10):1908-10.
We compared the clinical sensitivity and cost-effectiveness of a qualitative assay for choriogonadotropin in human urine ("Icon" hCG) with a quantitative assay of serum from 142 women with pathologically-diagnosed ectopic pregnancy. Results show that although the qualitative assay had a clinical sensitivity for pregnancy of 98.6%, as compared to 100% for the quantitative assay, it was more economical to use, and had a significantly shorter turnaround time. We conclude that qualitative hCG assay of either urine or serum is a good screening method for detecting pregnancy, and can replace the stat quantitative assay in women with suspected ectopic pregnancy. We present a diagnostic algorithm to illustrate the role of qualitative and quantitative hCG assays in conjunction with ultrasonography, culdocentesis, and laparoscopy for diagnosis of ectopic pregnancy.
我们比较了一种用于检测人尿中绒毛膜促性腺激素的定性检测方法（“Icon”hCG）与一种用于检测血清的定量检测方法对142例经病理诊断为异位妊娠的女性的临床敏感性和成本效益。结果显示，尽管定性检测方法对妊娠的临床敏感性为98.6%，而定量检测方法为100%，但定性检测方法使用起来更经济，且周转时间明显更短。我们得出结论，尿或血清的定性hCG检测是检测妊娠的一种良好筛查方法，并且可以替代疑似异位妊娠女性的即时定量检测。我们提出一种诊断算法来说明定性和定量hCG检测结合超声检查、后穹窿穿刺术和腹腔镜检查在异位妊娠诊断中的作用。
