College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou, 310018, People's Republic of China.
Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong, Hong Kong.
Mikrochim Acta. 2018 Jan 8;185(2):87. doi: 10.1007/s00604-017-2646-9.
Nitrogen doped carbon dots (NCDs) were synthesized using a low temperature approach and used to modify a glassy carbon electrode (GCE) via dipping. The oxygen groups on the surface of the NCDs, and the charge delocalization of the NCDs warrant an excellent electrocatalytic activity of the GCE toward oxidation of paracetamol (PA) and reduction of HO. PA and HO were detected at 0.34 V and -0.4 V (both vs. Ag/AgCl) using differential pulse voltammetry and amperometric I-T measurement, respectively. The modified GCE has a linear response to PA in the 0.5 to 600 μM concentration range, and to HO in the 0.05 μM to 2.25 mM concentration range. The detection limits are 157 nM and 41 nM, respectively. In our perception, the modified GCE holds promise for stable, selective and sensitive determination of PA and HO in pharmaceutical analysis. Graphic abstract Nitrogen doped carbon dots (NCDs) were synthesized and used to modify a glassy carbon electrode. Surface functional groups on NCDs can trigger electrocatalytic reactions toward paracetamol oxidation and HO reduction with high sensitivities.
氮掺杂碳点（NCDs）通过低温方法合成，并通过浸渍法用于修饰玻碳电极（GCE）。NCDs 表面的氧基团和 NCDs 的电荷离域赋予了 GCE 对扑热息痛（PA）氧化和 HO 还原的优异电催化活性。使用差分脉冲伏安法和安培计时电流法分别在 0.34 V 和-0.4 V（均相对于 Ag/AgCl）检测到 PA 和 HO。修饰后的 GCE 对 0.5 至 600 μM 浓度范围内的 PA 和 0.05 μM 至 2.25 mM 浓度范围内的 HO 具有线性响应。检测限分别为 157 nM 和 41 nM。在我们看来，修饰后的 GCE 有望用于药物分析中 PA 和 HO 的稳定、选择性和灵敏测定。
