1 Department of Acupuncture, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
Am J Chin Med. 2018;46(3):515-535. doi: 10.1142/S0192415X1850026X. Epub 2018 Mar 29.
Apoptosis, known as programmed cell death, plays a significant role in the pathogenesis of neurological diseases. Most of these diseases can be obviously alleviated by means of acupuncture treatment. Current research studies have shown that the efficacy of acupuncture to these medical conditions is closely associated with the anti-apoptotic potentials. Mainly based on the acupuncture's anti-apoptotic efficacy in prevalent neurological disorders, including cerebral ischemia-reperfusion injury, Alzheimer's disease, depression or stress related-modes, spinal cord injuries, etc., this review comes to a conclusion that the anti-apoptotic effect of acupuncture treatment for neurological diseases, evidently reflected through Bcl-2, Bax or caspase expression change, results from regulating mitochondrial or autophagic dysfunction as well as reducing oxidative stress and inflammation. The possible mechanisms of acupuncture's anti-apoptotic effect are associated with a series of downstream signaling pathways and the up-regulated expression of neurotrophic factors. It is of great importance to illuminate the exact mechanisms of acupuncture treatment for neurological dysfunctions.
细胞凋亡，亦称程序性细胞死亡，在神经疾病的发病机制中起着重要作用。大多数这类疾病都可以通过针刺疗法明显缓解。目前的研究表明，针刺治疗这些病症的疗效与抗凋亡潜能密切相关。主要基于针刺在常见神经疾病中的抗凋亡功效，包括脑缺血再灌注损伤、阿尔茨海默病、抑郁或应激相关模式、脊髓损伤等，本综述得出结论，针刺治疗神经疾病的抗凋亡作用，通过 Bcl-2、Bax 或 caspase 表达的变化明显体现，这是通过调节线粒体或自噬功能障碍以及减少氧化应激和炎症实现的。针刺抗凋亡作用的可能机制与一系列下游信号通路和神经营养因子的上调表达有关。阐明针刺治疗神经功能障碍的确切机制非常重要。
