Li Jinting, Wu Minmin, Song Wenjing, Zhang Jiongliang, Zhu Luwen
Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
The Second Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Parkinsons Dis. 2025 May 11;2025:9739567. doi: 10.1155/padi/9739567. eCollection 2025.
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, and the mainstay of treatment is dopamine replacement therapy; however, its beneficial effects tend to wane over time as the disease progresses. Many patients seek complementary therapies to alleviate motor and nonmotor symptoms associated with PD, and the efficacy of acupuncture as a commonly used complementary and alternative therapy for PD remains controversial. In this review, we systematically examine randomized controlled trials and mechanistic studies on acupuncture for PD over the past 12 years. The findings indicate that acupuncture improves both motor and nonmotor symptoms. We also found that the mechanisms underlying the effects of acupuncture on PD may involve connectomics, modulation of dopamine and glutamate systems, regulation of the gut-brain axis, organelle homeostasis, and molecular and signaling pathway modulation. This review proposes a multitarget neuroprotection hypothesis to provide a theoretical basis for standardized acupuncture research.
帕金森病（PD）是全球第二常见的神经退行性疾病，其主要治疗方法是多巴胺替代疗法；然而，随着疾病进展，其有益效果往往会随着时间的推移而减弱。许多患者寻求辅助疗法来缓解与PD相关的运动和非运动症状，而针灸作为一种常用于PD的辅助和替代疗法，其疗效仍存在争议。在本综述中，我们系统地研究了过去12年中关于针灸治疗PD的随机对照试验和机制研究。研究结果表明，针灸可改善运动和非运动症状。我们还发现，针灸对PD产生作用的潜在机制可能涉及连接组学、多巴胺和谷氨酸系统的调节、肠-脑轴的调控、细胞器稳态以及分子和信号通路的调节。本综述提出了多靶点神经保护假说，为标准化针灸研究提供理论依据。
