Žlnay Martin
Vnitr Lek. 2018 Spring;64(2):117-126.
Axial spondyloarthritis (SpA) is a chronic inflammatory rheumatic disorder that primary affects axial skeleton. It comprises wide spectrum of patients with immune mediated spine inflammation, from early, so called non-radiographic axial spondyloarthritis to clinically evident ankylosing spondylitis. Conventional radiography is still the cornerstone of diagnosis, evaluation and classification of SpA. However, it has limitations in early disease, because it can only depict the consequences of inflammation for its inability to visualize soft tissue abnormalities within bone marrow. Magnetic resonance imaging (MRI) is superior to conventional radiography in early disease through its ability to visualize active inflammatory changes in sacroiliac joints when the pelvic radiographs are normal or equivocal. MRI of sacroiliac joints is also included to the Assessment of Axial Spondyloarthritis (ASAS) classification criteria for axial SpA. For classification purposes positive definition of MRI sacroiliitis was proposed with the clear presence of subchondral bone marrow edema (osteitis), which does not cross anatomical borders and is usually present on more consecutive slides. The more intense the signal is on fluid sensitive MRI sequences; more likely it reflects active inflammation, because small focal bone marrow edema lesions may occur in patients with mechanical back pain. It may be associated with signs of structural damage such as erosions, which can enhance diagnostic utility of MRI in cases of not highly suggestive appearance of osteitis. Contrast-enhanced imaging is not useful for routine diagnostic evaluation. When MRI findings are not clear, an additional MRI of the spine can be performed, especially of the area with the most pronounced complaints. Evidence of bone marrow edema in three or more vertebral edges is considered as highly suggestive of axial SpA, especially in patients of younger age, when degenerative changes are expected to play minor role for differential diagnosis.Key words: ankylosing spondylitis - axial spondyloarthritis - magnetic resonance imaging (MRI) - sacroiliitis.
轴性脊柱关节炎(SpA)是一种主要影响中轴骨骼的慢性炎症性风湿性疾病。它涵盖了广泛的免疫介导性脊柱炎症患者,从早期所谓的非放射学轴性脊柱关节炎到临床明显的强直性脊柱炎。传统放射学检查仍是SpA诊断、评估和分类的基石。然而,它在疾病早期存在局限性,因为其无法显示骨髓内的软组织异常,只能描绘炎症的后果。磁共振成像(MRI)在疾病早期优于传统放射学检查,因为当骨盆X线片正常或不明确时,它能够显示骶髂关节的活动性炎症变化。骶髂关节MRI也被纳入轴性脊柱关节炎(ASAS)的轴性SpA分类标准。为了分类目的,提出了MRI骶髂关节炎的阳性定义,即明确存在不跨越解剖边界且通常出现在连续多张切片上的软骨下骨髓水肿(骨炎)。在液体敏感的MRI序列上信号越强,越有可能反映活动性炎症,因为机械性背痛患者可能会出现小的局灶性骨髓水肿病变。它可能与侵蚀等结构损伤迹象相关,这可以提高MRI在骨炎表现不具高度提示性的病例中的诊断效用。对比增强成像对常规诊断评估无用。当MRI结果不明确时,可以进行额外的脊柱MRI检查,尤其是对主诉最明显的部位。三个或更多椎体边缘出现骨髓水肿的证据高度提示轴性SpA,特别是在年轻患者中,此时退行性改变在鉴别诊断中预计起次要作用。关键词:强直性脊柱炎 - 轴性脊柱关节炎 - 磁共振成像(MRI) - 骶髂关节炎