调节人类金属硫蛋白基因表达的转录控制机制。
Transcriptional control mechanisms which regulate the expression of human metallothionein genes.
作者信息
Karin M, Haslinger A, Heguy A, Dietlin T, Imbra R
机构信息
Department of Microbiology, University of Southern California, School of Medicine, Los Angeles 90033.
出版信息
Experientia Suppl. 1987;52:401-5. doi: 10.1007/978-3-0348-6784-9_38.
The human genome contains at least 12 distinct metallothionein genes. The expression of these genes is regulated at the transcriptional levels by heavy metal ions, steroid hormones, interferon, interleukin 1 and phorbol esters. Comparisons of metallothionein gene sequences reveals a higher level of heterogeneity in the 5' flanking control regions than in the coding regions. This is due to the presence of distinct promoter elements on each of the genes. These elements are responsible for inducer and tissue specificity of metallothionein gene expression.
人类基因组至少包含12个不同的金属硫蛋白基因。这些基因的表达在转录水平上受到重金属离子、类固醇激素、干扰素、白细胞介素1和佛波酯的调控。金属硫蛋白基因序列的比较显示，5'侧翼控制区的异质性水平高于编码区。这是由于每个基因上存在不同的启动子元件。这些元件负责金属硫蛋白基因表达的诱导剂和组织特异性。
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