Activation of delta-aminolevulinic acid dehydratase following donation of zinc from kidney metallothionein. - Suppr | 超能文献

Activation of delta-aminolevulinic acid dehydratase following donation of zinc from kidney metallothionein.

作者信息

Goering P L, Fowler B A

机构信息

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

出版信息

Experientia Suppl. 1987;52:613-6. doi: 10.1007/978-3-0348-6784-9_64.

DOI:10.1007/978-3-0348-6784-9_64

Abstract

Metallothionein has been postulated to function in essential metal homeostasis. In this study, we demonstrate a 1.7-fold increase in purified bovine liver delta-aminolevulinic acid dehydratase (ALAD) activity following incubation with purified kidney Zn-thionein isolated from Zn-treated rats. The mechanism of enzyme activation, as demonstrated using 65Zn-labeled thionein, involves direct transfer of Zn from Zn-thionein to ALAD. These data support the hypothesis that metallothionein serves to regulate the intracellular bioavailability of essential cations, functioning as a reservoir or conduit through which metals are donated to enzymes which require them as cofactors.

摘要

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