Arutiunian R S
Fiziol Zh SSSR Im I M Sechenova. 1987 Jul;73(7):902-7.
The effect of preliminary injection of the inhibitor of protein synthesis actinomycin D on development of extrajunctional cholinergic receptors in denervated intrafusal muscle in cats, was investigated. Chronic motor denervation of the soleus muscle (3-5 days after denervation) caused supersensitivity of intrafusal muscle fibres to acetylcholine (Ah), subecholine (SCh) and succinylcholine (Sh). Injections of actinomycin D prevented the supersensitivity, the latter being dependent on the synthesis of new cholinoreceptors and their incorporation in the extrajunctional region of intrafusal fibres.
研究了预先注射蛋白质合成抑制剂放线菌素D对猫失神经支配的梭内肌中接头外胆碱能受体发育的影响。比目鱼肌的慢性运动去神经支配（去神经支配后3 - 5天）导致梭内肌纤维对乙酰胆碱（Ah）、丁酰胆碱（SCh）和琥珀酰胆碱（Sh）超敏。注射放线菌素D可防止超敏反应，后者依赖于新胆碱能受体的合成及其在梭内纤维接头外区域的整合。
