Meng Ge, Li Huihui, Li Yajun, Zhang Qing, Liu Li, Wu Hongmei, Xia Yang, Bao Xue, Gu Yeqing, Su Qian, Fang Liyun, Yang Huijun, Yu Fei, Shi Hongbin, Sun Shaomei, Wang Xing, Zhou Ming, Jia Qiyu, Song Kun, Chang Hong, Wu Yuntang, Niu Kaijun
1 Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University , Tianjin, China .
2 Health Management Centre, Tianjin Medical University General Hospital , Tianjin, China .
Metab Syndr Relat Disord. 2018 Apr;16(3):143-149. doi: 10.1089/met.2017.0111. Epub 2018 Mar 12.
Metabolic syndrome (MetS) is a cluster of cardiovascular and metabolic risk factors in the same individual. Inflammation has been reported to be directly involved in the development of metabolic disease. Complement component 3 (C3) and complement component 4 (C4) have been identified as important inflammatory markers relevant to metabolic disease. However, few studies have analyzed the association between C3 and/or C4 and MetS. In this study, our aim is to evaluate sex-specific association between C3 and C4 levels and risk of MetS in an adult population.
A cohort of 4635 adults was followed from 2010 to 2016. Serum C3 and C4 levels were measured using an immunonephelometric technique. MetS was defined by the American Heart Association scientific statements of 2009. Cox proportional hazard regression models were used to assess sex-specific association between C3 and C4 levels and the incidence of MetS.
During the ∼6 years of follow-up, 1445 new cases of MetS were identified. After being adjusted to confounding factors, the hazard ratios (95% confidence interval) of MetS for gradually increasing quintiles of C3 were 1.00, 1.23 (0.98-1.54), 1.50 (1.21-1.87), 1.64 (1.32-2.04), and 1.75 (1.41-2.18) (P for trend <0.0001) in men and 1.00, 0.96 (0.60-1.53), 1.61 (1.06-2.44), 2.01 (1.34-3.03), and 2.43 (1.63-3.63) (P for trend <0.0001) in women, respectively. Similar results were also obtained for gradually increasing quintiles of C4 in women, but not in men.
The levels of C3 were significantly associated with the incidence of MetS in both men and women. The levels of C4 contributed to risk of MetS only in women.
代谢综合征（MetS）是指同一个体中存在的一组心血管和代谢风险因素。据报道，炎症直接参与代谢性疾病的发生发展。补体成分3（C3）和补体成分4（C4）已被确定为与代谢性疾病相关的重要炎症标志物。然而，很少有研究分析C3和/或C4与代谢综合征之间的关联。在本研究中，我们的目的是评估成年人群中C3和C4水平与代谢综合征风险之间的性别特异性关联。
对4635名成年人组成的队列进行了2010年至2016年的随访。采用免疫比浊技术测定血清C3和C4水平。代谢综合征根据美国心脏协会2009年的科学声明进行定义。使用Cox比例风险回归模型评估C3和C4水平与代谢综合征发病率之间的性别特异性关联。
在约6年的随访期间，共确定了1445例新的代谢综合征病例。在对混杂因素进行调整后，男性中C3水平逐渐升高的五分位数对应的代谢综合征风险比（95%置信区间）分别为1.00、1.23（0.98 - 1.54）、1.50（1.21 - 1.87）、1.64（1.32 - 2.04）和1.75（1.41 - 2.18）（趋势P值<0.0001），女性中分别为1.00、0.96（0.60 - 1.53）、1.61（1.06 - 2.44）、2.01（1.34 - 3.03）和2.43（1.63 - 3.63）（趋势P值<0.0001）。女性中C4水平逐渐升高的五分位数也得到了类似结果，但男性中未观察到。
C3水平在男性和女性中均与代谢综合征的发病率显著相关。C4水平仅在女性中增加代谢综合征的风险。
