• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Flupirtine, an Effective Analgesic, but Hepatotoxicity Should Limit Its Use.

作者信息

Puljak Livia

机构信息

Laboratory for Pain Research, University of Split School of Medicine, Split, Croatia, Department of Development, Research, and Health Technology Assessment, Agency for Quality and Accreditation in Health Care and Social Welfare, Zagreb, Croatia,

出版信息

Anesth Analg. 2018 Jul;127(1):309-310. doi: 10.1213/ANE.0000000000003355.

DOI:10.1213/ANE.0000000000003355
PMID:29596091
Abstract
摘要

相似文献

1
Flupirtine, an Effective Analgesic, but Hepatotoxicity Should Limit Its Use.氟吡汀是一种有效的镇痛药,但肝毒性应限制其使用。
Anesth Analg. 2018 Jul;127(1):309-310. doi: 10.1213/ANE.0000000000003355.
2
Structure-Activity Relationships of Flupirtine Analogues for Liver Esterase-Mediated Cleavage of the 4-Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity.氟比洛芬类似物的结构-活性关系,用于肝酯酶介导的 4-氟苄基胺部分的切割,及其与肝毒性的可能相关性。
ChemMedChem. 2023 Jul 17;18(14):e202300145. doi: 10.1002/cmdc.202300145. Epub 2023 May 31.
3
Flupirtine Is an Effective Analgesic: Is the Associated Rare Liver Injury a Limiting Factor to Its Use?氟吡汀是一种有效的镇痛药:与之相关的罕见肝损伤是其使用的限制因素吗?
Anesth Analg. 2018 Aug;127(2):e24-e25. doi: 10.1213/ANE.0000000000003436.
4
In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury.采用体外方法阐明羧酸酯酶 2 和 N-乙酰基转移酶 2 与氟吡汀肝损伤的相关性。
Biochem Pharmacol. 2018 Sep;155:242-251. doi: 10.1016/j.bcp.2018.07.019. Epub 2018 Jul 17.
5
Flupirtine-induced liver injury--seven cases from the Berlin Case-control Surveillance Study and review of the German spontaneous adverse drug reaction reporting database.氟吡汀致肝损伤——来自柏林病例对照监测研究的 7 例病例和德国自发药物不良反应报告数据库的回顾。
Eur J Clin Pharmacol. 2014 Apr;70(4):453-9. doi: 10.1007/s00228-013-1631-4. Epub 2013 Dec 24.
6
[The pharmacologic effect of flupirtine, a structurally new analgesic].[氟吡汀的药理作用,一种结构新颖的镇痛药]
Arzneimittelforschung. 1985;35(1):30-43.
7
[Flupirtine helps - but pay attention to the liver!].[氟吡汀有帮助——但要注意肝脏!]
Med Monatsschr Pharm. 2015 Apr;38(4):149-50.
8
Flupirtine-induced hepatic failure requiring orthotopic liver transplant.氟吡汀诱发的肝衰竭需进行原位肝移植。
Exp Clin Transplant. 2011 Aug;9(4):270-2.
9
N-acetylcysteine and prednisolone treatment improved serum biochemistries in suspected flupirtine cases of severe idiosyncratic liver injury.N-乙酰半胱氨酸和泼尼松龙治疗改善了疑似氟吡汀致严重特异质肝损伤病例的血清生化指标。
Liver Int. 2018 Feb;38(2):365-376. doi: 10.1111/liv.13538. Epub 2017 Sep 8.
10
Flupirtine. A review of its pharmacological properties, and therapeutic efficacy in pain states.氟吡汀。其药理特性及在疼痛状态下治疗效果的综述。
Drugs. 1993 Apr;45(4):548-69. doi: 10.2165/00003495-199345040-00007.

引用本文的文献

1
Signals from randomized clinical trials predicting hepatotoxicity of flupirtine: systematic review.预测氟吡汀肝毒性的随机临床试验信号:系统评价
Eur J Clin Pharmacol. 2025 Apr 23. doi: 10.1007/s00228-025-03840-8.
2
Pharmacological Activation of Neuronal Voltage-Gated Kv7/KCNQ/M-Channels for Potential Therapy of Epilepsy and Pain.神经元电压门控 Kv7/KCNQ/M 通道的药理学激活用于癫痫和疼痛的潜在治疗。
Handb Exp Pharmacol. 2021;267:231-251. doi: 10.1007/164_2021_458.
3
Hulk-Like Urine: A Case of Green Urine Caused by Flupirtine Intoxication.
绿巨人般的尿液:一例因氟吡汀中毒导致的绿色尿液病例。
Cureus. 2020 Dec 28;12(12):e12333. doi: 10.7759/cureus.12333.