Bellosta M, Vignini M, Miori L, Rabbiosi G
Clinica Dermatologica, University of Pavia, Italy.
Int J Tissue React. 1987;9(5):443-6.
A selected group of 60 patients who had been resistant to previous systemic antibiotic therapy was treated with low-dose isotretinoin (0.5 mg/kg/day in two doses) for 12 to 20 weeks. The results confirmed the efficacy of the drug on pustular, nodular and cystic acne even with low-dose treatment. In only one case was it necessary to suspend the treatment because of an increase in serum cholesterol and triglycerides. The authors therefore advise the use of low dosage and that treatment should be restricted to cases of severe acne.
选取了60名对先前全身抗生素治疗有抗性的患者，用低剂量异维A酸（0.5毫克/千克/天，分两次服用）治疗12至20周。结果证实，即使是低剂量治疗，该药物对脓疱性、结节性和囊肿性痤疮也有效。仅1例因血清胆固醇和甘油三酯升高而有必要暂停治疗。因此，作者建议采用低剂量用药，且治疗应限于重度痤疮病例。
