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A new strategy to decrease cardiac injury in aged heart following ischaemia-reperfusion: enhancement of the interaction between AMPK and SIRT1.

作者信息

Chen Qun, Lesnefsky Edward J

机构信息

Department of Medicine, Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

出版信息

Cardiovasc Res. 2018 May 1;114(6):771-772. doi: 10.1093/cvr/cvy062.

DOI:10.1093/cvr/cvy062
PMID:29596586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5909644/
Abstract
摘要

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本文引用的文献

1
Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury.心肌细胞特异性敲除 Sirt1 基因使心肌易受缺血再灌注损伤。
Cardiovasc Res. 2018 May 1;114(6):805-821. doi: 10.1093/cvr/cvy033.
2
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway.Sestrin2 通过 AMPK/PGC-1α 通路预防与年龄相关的心肌梗死后不耐受。
J Mol Cell Cardiol. 2018 Feb;115:170-178. doi: 10.1016/j.yjmcc.2018.01.005. Epub 2018 Jan 8.
3
Activation of the AMPK/Sirt1 pathway by a leucine-metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans.亮氨酸-二甲双胍联合激活 AMPK/Sirt1 通路可增加骨骼肌胰岛素敏感性，并刺激葡萄糖和脂质代谢，延长秀丽隐杆线虫的寿命。
Metabolism. 2016 Nov;65(11):1679-1691. doi: 10.1016/j.metabol.2016.06.011. Epub 2016 Jul 9.
4
Mitochondrial Metabolism in Aging Heart.衰老心脏中的线粒体代谢
Circ Res. 2016 May 13;118(10):1593-611. doi: 10.1161/CIRCRESAHA.116.307505.
5
Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release.线粒体钙蛋白酶的激活与心脏损伤加剧：超越凋亡诱导因子的释放
Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H376-84. doi: 10.1152/ajpheart.00748.2015. Epub 2015 Dec 4.
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Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart. sestrin2 促进缺血心脏中 LKB1 介导的 AMPK 激活。
FASEB J. 2015 Feb;29(2):408-17. doi: 10.1096/fj.14-258814. Epub 2014 Nov 3.
7
Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon.慢性二甲双胍相关的心肌梗死保护作用：不仅仅是降低血糖的现象。
Cardiovasc Drugs Ther. 2013 Feb;27(1):5-16. doi: 10.1007/s10557-012-6425-x.
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Metabolic therapy at the crossroad: how to optimize myocardial substrate utilization?代谢治疗的十字路口：如何优化心肌底物利用？
Trends Cardiovasc Med. 2009 Aug;19(6):201-7. doi: 10.1016/j.tcm.2009.12.005.
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Activating SIRT1: a new strategy to prevent atherosclerosis?激活沉默信息调节因子1：预防动脉粥样硬化的新策略？
Cardiovasc Res. 2008 Nov 1;80(2):163-4. doi: 10.1093/cvr/cvn245. Epub 2008 Sep 10.
10
Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.急性二甲双胍治疗通过AMPK-eNOS介导的信号通路对心肌梗死具有心脏保护作用。
Diabetes. 2008 Mar;57(3):696-705. doi: 10.2337/db07-1098. Epub 2007 Dec 14.