Beitman B D, Basha I, Flaker G, DeRosear L, Mukerji V, Lamberti J W
Department of Psychiatry, University of Missouri, Columbia School of Medicine 65212.
J Affect Disord. 1987 Jul-Aug;13(1):51-9. doi: 10.1016/0165-0327(87)90073-5.
104 patients in a cardiology clinic with atypical or non-anginal chest pain were studied through a structured clinical interview. 43 without coronary artery disease fit diagnostic criteria for panic disorder. 19 (44%) of this group reported a lifetime prevalence of major depression, nine (21%) current and ten (23%) past only. Nine reported that their major depressive episodes had preceded the onset of their panic disorder. On many self-report questionnaire scales the group with a lifetime history of major depression (n = 19) differed significantly from the group with no lifetime history of major depression (n = 24). These differences, however, could be attributed primarily to the group with current major depression. There appears to be a subgroup of panic disorder patients who have current major depression who are more symptomatic than those with panic disorder and past major depression and panic disorder alone. These findings also suggest that the association between panic disorder and depression may remain high outside of psychiatric settings.
通过结构化临床访谈对心脏病诊所中104例患有非典型或非心绞痛性胸痛的患者进行了研究。43例无冠状动脉疾病的患者符合惊恐障碍的诊断标准。该组中有19例（44%）报告有重度抑郁症的终生患病率，其中9例（21%）为当前患病，10例（23%）仅为过去患病。9例报告其重度抑郁发作先于惊恐障碍发作。在许多自我报告问卷量表上，有重度抑郁症终生病史的组（n = 19）与无重度抑郁症终生病史的组（n = 24）有显著差异。然而，这些差异主要可归因于当前患有重度抑郁症的组。似乎有一部分患有当前重度抑郁症的惊恐障碍患者比那些患有惊恐障碍和过去重度抑郁症以及仅患有惊恐障碍的患者症状更明显。这些发现还表明，在精神科环境之外，惊恐障碍与抑郁症之间的关联可能仍然很高。
