Ardizzi A, Barberis S, Giorgis G E, Oliaro A, Galietti F, Ciotta D
Ospedale Pneumologico San Luigi Gonzaga, Orbassano, Torino.
Minerva Med. 1987 Oct 15;78(19):1433-5.
The bronchodilatory activity of one beta 2-stimulation (procaterol) and one calcium antagonist (nicardipine) both recently introduced was compared in a group of chronic asthmatics in the clinical remission phase. The experiment took the form of the randomised double blind administration of procaterol or nicardipine or a placebo twice a day for 15 days with spirometric tests being performed before, during and after the experiment. The results show that nicardipine does have a bronchodilatory effect though less than the beta 2-stimulant.
对一组处于临床缓解期的慢性哮喘患者,比较了最近引入的一种β2受体激动剂(丙卡特罗)和一种钙拮抗剂(尼卡地平)的支气管扩张活性。实验采用随机双盲法,将丙卡特罗、尼卡地平或安慰剂每日给药两次,共15天,并在实验前、实验期间和实验后进行肺活量测定。结果表明,尼卡地平确实有支气管扩张作用,尽管比β2受体激动剂的作用小。