墨西哥西北部患者三支血管冠状动脉疾病的危险因素

Risk factors for three-vessel coronary artery disease in patients of Northwest Mexico.

作者信息

Arroyo-Rodríguez Cuitlahuac, Brito-Zurita Olga Rosa, Sandoval-Navarrete Santiago, Solis-Vásquez Rogelio, Ornelas-Aguirre José Manuel, Olea-Hernández Celestino, Vásquez-Serna César, Castelan-Ojeda Amanda Marcela

机构信息

Cardiology Department, Hospital Number 2, High Specialty Medical Unit, Northwest National Medical Center of the Instituto Mexicano del Seguro Social at Ciudad Obregón, Sonora, Mexico.

Medical Center of the South of Sonora at Ciudad Obregón, Sonora, Mexico.

出版信息

Arch Cardiol Mex. 2018 Dec;88(5):423-431. doi: 10.1016/j.acmx.2018.02.009. Epub 2018 Mar 26.

DOI:10.1016/j.acmx.2018.02.009

PMID:29598917

Abstract

INTRODUCTION

Three-vessel coronary artery disease is an advanced manifestation of atherosclerosis, with high prevalence in Mexico.

OBJECTIVE

The aim of this study was to describe coronary risk factors in a group of patients with three-vessel coronary artery disease in Northwest Mexico.

METHODS

A cross sectional study was conducted on a population with three-vessel coronary artery disease from May 2015 to February 2016. The disease was defined when ≥70% stenosis was present in each major epicardial coronary artery. Anthropometric and biochemical parameters were measured in each patient. Ankle-Brachial Index was measured with vascular ultrasound, and Syntax score calculation with an on-line application. Statistical analysis for qualitative differences was performed using Pearson X test, with p<0.05 being considered as significant.

RESULTS

The study included 100 patients, of whom 75 were male (mean age 63±9 years) and 25 female (mean age 69±9 years). The coronary risk factors observed were diabetes (58%), hypertension (86%), smoking (68%), dyslipidaemia (100%), metabolic syndrome (71%), and obesity/overweight (75%). Diabetes and metabolic syndrome prevalence was higher in women (p=0.03), but smoking was higher in men (76%, p=0.003). Ankle-Brachial Index was abnormal in 58% of patients, the mean Syntax score was in 36.9±11.5, and the prevalence of left main coronary heart disease was 36%.

CONCLUSIONS

This group of patients with complex coronary lesions has a high prevalence of coronary risk factors, which could represent a worse prognosis.

摘要

引言

三支血管冠状动脉疾病是动脉粥样硬化的一种晚期表现，在墨西哥患病率很高。

目的

本研究的目的是描述墨西哥西北部一组三支血管冠状动脉疾病患者的冠状动脉危险因素。

方法

于2015年5月至2016年2月对患有三支血管冠状动脉疾病的人群进行了一项横断面研究。当每支主要心外膜冠状动脉狭窄≥70%时定义为该疾病。测量了每位患者的人体测量和生化参数。用血管超声测量踝臂指数，并用在线应用程序计算Syntax评分。使用Pearson X检验对定性差异进行统计分析，p<0.05被认为具有统计学意义。

结果

该研究纳入了100名患者，其中75名男性（平均年龄63±9岁）和25名女性（平均年龄69±9岁）。观察到的冠状动脉危险因素包括糖尿病（58%）、高血压（86%）、吸烟（68%）、血脂异常（100%）、代谢综合征（71%）和肥胖/超重（75%）。女性糖尿病和代谢综合征的患病率较高（p=0.03），但男性吸烟率较高（76%，p=0.003）。58%的患者踝臂指数异常，平均Syntax评分为36.9±11.5，左主干冠心病的患病率为36%。