Brands Anne-Mieke E F, Schmidt Anton J M
Department of Medical Psychology, University of Limburg, MaastrichtThe Netherlands.
Pain. 1987 Sep;30(3):329-337. doi: 10.1016/0304-3959(87)90021-2.
Twenty-one chronic low back pain (CLBP) patients and 20 control subjects participated in 8 successive cold pressor tests (CPT). The hypotheses were that: (1) CLBP patients would demonstrate poorer acute pain tolerance and report higher acute pain, and (2) CLBP patients would become sensitized during 8 successive CPT trials, while control subjects would habituate, resulting in increasing differences in test behavior between both groups. The results show that the first hypothesis was confirmed. The second hypothesis requires modification, as the control group both habituated and became sensitized, while within the CLBP group no learning or training effect was found. These findings lead one to conclude that the deviant acute pain behavior of CLBP patient may be regarded either as a consequence of CLBP or as an important risk factor in the development of CLBP. Patients with relatively high CLBP levels performed poorly on the CPT as compared with patients with relatively low CLBP levels.
21名慢性下腰痛（CLBP）患者和20名对照受试者参加了8次连续的冷加压试验（CPT）。研究假设如下：（1）CLBP患者的急性疼痛耐受性较差，报告的急性疼痛程度较高；（2）CLBP患者在8次连续的CPT试验中会产生敏化，而对照受试者会产生习惯化，导致两组之间的测试行为差异增大。结果表明，第一个假设得到了证实。第二个假设需要修正，因为对照组既产生了习惯化又产生了敏化，而在CLBP组中未发现学习或训练效果。这些发现使人们得出结论，CLBP患者异常的急性疼痛行为可能被视为CLBP的结果，也可能是CLBP发展的一个重要风险因素。与CLBP水平相对较低的患者相比，CLBP水平相对较高的患者在CPT上表现较差。
