Kok M K, Chambers J K, Ushio N, Miwa Y, Nakayama H, Uchida K
Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan.
Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan.
J Comp Pathol. 2018 Feb;159:26-30. doi: 10.1016/j.jcpa.2017.12.002. Epub 2018 Feb 6.
A 6-year-old female black-tailed prairie dog (Cynomys ludovicianus) was presented with a space-occupying lesion in the left submandibular region. On computed tomography, a low attenuating, poorly circumscribed mass infiltrated the left mandibular bone, with osteolytic change. Microscopically, the lesion was composed of odontogenic epithelium proliferating in nests and embedded in abundant dental papilla-like ectomesenchyme, including dentine and enamel. Multifocal amyloid deposition was observed. Immunohistochemically, the neoplastic epithelial cells were positive for cytokeratin (CK) AE1/AE3, CK14 and p63. Some epithelial cells were positive for amelogenin and some adjacent to the amyloid deposits co-expressed S100. The ectomesenchymal cells expressed vimentin and strong S100 immunoreactivity was observed in odontoblast-like cells. The amyloid was immunolabelled with amelogenin. The tumour was diagnosed as amyloid-producing odontoameloblastoma.
一只6岁雌性黑尾土拨鼠（草原犬鼠）因左下颌下区出现占位性病变前来就诊。计算机断层扫描显示，一个低密度、边界不清的肿块浸润左下颌骨，伴有骨质溶解改变。显微镜下，病变由呈巢状增殖并包埋于丰富牙乳头样外胚间充质中的牙源性上皮组成，包括牙本质和釉质。观察到多灶性淀粉样沉积。免疫组织化学检查显示，肿瘤性上皮细胞细胞角蛋白（CK）AE1/AE3、CK14和p63呈阳性。一些上皮细胞釉原蛋白呈阳性，一些与淀粉样沉积物相邻的细胞共表达S100。外胚间充质细胞波形蛋白呈阳性，在成牙本质细胞样细胞中观察到强烈的S100免疫反应性。淀粉样物质用釉原蛋白进行免疫标记。该肿瘤被诊断为产生淀粉样物质的成釉牙本质细胞瘤。
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