Fukushima Hiroshi, Kobayashi Masaki, Kawano Keizo, Morimoto Shinji
Department of Urology, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan
Department of Urology, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan.
Anticancer Res. 2018 Apr;38(4):2329-2334. doi: 10.21873/anticanres.12478.
BACKGROUND/AIM: We investigated the prognostic role of the albumin/globulin ratio (AGR) in patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU).
AGR was calculated as follows: AGR=serum albumin/(serum total protein-serum albumin). Associations of preoperative AGR with disease-free (DFS) and overall (OS) survival were assessed in 105 patients with UTUC undergoing RNU.
Patients with preoperative AGR <1.24 and ≥1.24 were classified into the low (n=46, 44%) and high (n=59, 56%) groups, respectively. The 5-year DFS and OS were 77% and 78%, respectively. On multivariate analysis, high preoperative AGR was an independent predictor for both better DFS (hazard ratio(HR)=0.34, p=0.038) and OS (HR=0.24, p=0.006). The 5-year DFS and OS were significantly longer in the high-AGR group than in the low-AGR group (90% vs. 60%; 89% vs. 65%, both p<0.001).
The AGR has prognostic value in patients with UTUC undergoing RNU.
背景/目的：我们研究了白蛋白/球蛋白比值（AGR）在上尿路尿路上皮癌（UTUC）患者接受根治性肾输尿管切除术（RNU）中的预后作用。
AGR的计算方法如下：AGR = 血清白蛋白/（血清总蛋白 - 血清白蛋白）。对105例接受RNU的UTUC患者评估术前AGR与无病生存期（DFS）和总生存期（OS）的相关性。
术前AGR <1.24和≥1.24的患者分别分为低（n = 46，44%）和高（n = 59，56%）组。5年DFS和OS分别为77%和78%。多因素分析显示，术前AGR高是DFS更好（风险比[HR]=0.34，p = 0.038）和OS更好（HR = 0.24，p = 0.006）的独立预测因素。高AGR组的5年DFS和OS显著长于低AGR组（90%对60%；89%对65%，p均<0.001）。
AGR在接受RNU的UTUC患者中具有预后价值。
