白蛋白/球蛋白比值在接受根治性肾输尿管切除术的上尿路尿路上皮癌患者中的预后价值
Prognostic Value of Albumin/Globulin Ratio in Patients with Upper Tract Urothelial Carcinoma Patients Treated with Radical Nephroureterectomy.
作者信息
Fukushima Hiroshi, Kobayashi Masaki, Kawano Keizo, Morimoto Shinji
机构信息
Department of Urology, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan
Department of Urology, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan.
出版信息
Anticancer Res. 2018 Apr;38(4):2329-2334. doi: 10.21873/anticanres.12478.
BACKGROUND/AIM: We investigated the prognostic role of the albumin/globulin ratio (AGR) in patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU).
PATIENTS AND METHODS
AGR was calculated as follows: AGR=serum albumin/(serum total protein-serum albumin). Associations of preoperative AGR with disease-free (DFS) and overall (OS) survival were assessed in 105 patients with UTUC undergoing RNU.
RESULTS
Patients with preoperative AGR <1.24 and ≥1.24 were classified into the low (n=46, 44%) and high (n=59, 56%) groups, respectively. The 5-year DFS and OS were 77% and 78%, respectively. On multivariate analysis, high preoperative AGR was an independent predictor for both better DFS (hazard ratio(HR)=0.34, p=0.038) and OS (HR=0.24, p=0.006). The 5-year DFS and OS were significantly longer in the high-AGR group than in the low-AGR group (90% vs. 60%; 89% vs. 65%, both p<0.001).
CONCLUSION
The AGR has prognostic value in patients with UTUC undergoing RNU.
背景/目的：我们研究了白蛋白/球蛋白比值（AGR）在上尿路尿路上皮癌（UTUC）患者接受根治性肾输尿管切除术（RNU）中的预后作用。
患者与方法
AGR的计算方法如下：AGR = 血清白蛋白/（血清总蛋白 - 血清白蛋白）。对105例接受RNU的UTUC患者评估术前AGR与无病生存期（DFS）和总生存期（OS）的相关性。
结果
术前AGR <1.24和≥1.24的患者分别分为低（n = 46，44%）和高（n = 59，56%）组。5年DFS和OS分别为77%和78%。多因素分析显示，术前AGR高是DFS更好（风险比[HR]=0.34，p = 0.038）和OS更好（HR = 0.24，p = 0.006）的独立预测因素。高AGR组的5年DFS和OS显著长于低AGR组（90%对60%；89%对65%，p均<0.001）。
结论
AGR在接受RNU的UTUC患者中具有预后价值。
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