Intraarterial prostaglandine E1 in arterial occlusive disease (AOD) stages III and IV.

Our physical, chemical and clinical findings - especially lactate, night pain and peripheral blood flow - have shown that in most cases of AOD stages III and IV, intraarterial infusions with prostaglandine E1 largely improved the peripheral situation. PGE1 seems to meliorate the blood flow - causing better oxygen supply - and to inhibit thrombocyte aggregation. An improvement of the clinical situation will be the result. In most cases a differentiation between responders and non-responders is possible but, on the other hand, it is not possible, however, to give a safe forecast of the success of this treatment in the individual patient.