Yun Seong-Hoon, Han Sang-Heum, Park Joo-In
Department of Biochemistry, Dong-A University College of Medicine, Busan, Republic of Korea.
PPAR Res. 2018 Jan 21;2018:6727421. doi: 10.1155/2018/6727421. eCollection 2018.
Peroxisome proliferator-activated receptor (PPAR) is part of a nuclear receptor superfamily that regulates gene expression involved in cell differentiation, proliferation, immune/inflammation response, and lipid metabolism. PPAR coactivator-1 (PGC-1), initially identified as a PPAR-interacting protein, is an important regulator of diverse metabolic pathways, such as oxidative metabolism and energy homeostasis. The role of PGC-1 in diabetes, neurodegeneration, and cardiovascular disease is particularly well known. PGC-1 is also now known to play important roles in cancer, independent of the role of PPAR in cancer. Though many researchers have studied the expression and clinical implications of PPAR and PGC-1 in cancer, there are still many controversies about the role of PPAR and PGC-1 in cancer. This review examines and summarizes some recent data on the role and action mechanisms of PPAR and PGC-1 in cancer, respectively, particularly the recent progress in understanding the role of PPAR in several cancers since our review was published in 2012.
过氧化物酶体增殖物激活受体（PPAR）是核受体超家族的一部分，该超家族调节参与细胞分化、增殖、免疫/炎症反应和脂质代谢的基因表达。PPAR共激活因子-1（PGC-1）最初被鉴定为与PPAR相互作用的蛋白，是多种代谢途径（如氧化代谢和能量稳态）的重要调节因子。PGC-1在糖尿病、神经退行性疾病和心血管疾病中的作用尤为著名。现在还已知PGC-1在癌症中发挥重要作用，独立于PPAR在癌症中的作用。尽管许多研究人员研究了PPAR和PGC-1在癌症中的表达及临床意义，但关于PPAR和PGC-1在癌症中的作用仍存在许多争议。本综述分别考察和总结了关于PPAR和PGC-1在癌症中的作用及作用机制的一些最新数据，特别是自我们2012年发表综述以来在理解PPAR在几种癌症中的作用方面的最新进展。
