复发缓解型多发性硬化症加重期循环抑制诱导性T淋巴细胞数量减少。

Reduction of circulating suppressor inducer T lymphocytes in the exacerbation phase of remitting-relapse multiple sclerosis.

作者信息

Cafaro A, Spadaro M, Pandolfi F, Tilia G, Scarselli E, Liberati F, Aiuti F

机构信息

Cattedra di Allergologia ed Immunologia Clinica, Università La Sapienza, Roma.

出版信息

Riv Neurol. 1987 May-Jun;57(3):159-62.

PMID:2960006

Abstract

We studied peripheral blood mononuclear cells (PBMC) from 34 multiple sclerosis (MS) patients: 8 had chronic progressive (CP) and 26 with a relapsing-remitting (RR) course. PBMC were tested with a panel of monoclonal antibodies (MoAbs) including anti-CD3, CD4, CD8, CD25 reagents. In addition, the suppressor inducer lymphocyte subset was investigated by using two color staining with anti-CD4 and G1-15 and/or anti-CD4 and anti-Leu-8 MoaAbs. A significant decrease of the suppressor inducer subset was found in the exacerbation phase of the RR form. Furthermore, a significant decrease of CD8+ (suppressor/cytotoxic) cells was shown in the remission phase of the RR group. Finally, CD25+ lymphocytes were significantly increased in both phases of RR form.

摘要

我们研究了34例多发性硬化症（MS）患者的外周血单个核细胞（PBMC）：其中8例为慢性进展型（CP），26例为复发缓解型（RR）病程。使用一组单克隆抗体（MoAb）对PBMC进行检测，包括抗CD3、CD4、CD8、CD25试剂。此外，通过用抗CD4和G1-15以及/或者抗CD4和抗Leu-8 MoAb进行双色染色来研究抑制诱导淋巴细胞亚群。在RR型的加重期发现抑制诱导亚群显著减少。此外，RR组缓解期CD8 +（抑制/细胞毒性）细胞显著减少。最后，RR型的两个阶段CD25 +淋巴细胞均显著增加。