Eichmann A, Eugster H P
Dermatologische Klinik, Universitätsspital Zürich.
Schweiz Med Wochenschr. 1987 Sep 12;117(37):1374-9.
From 1981-1985 2232 strains of Neisseria gonorrhoeae were isolated and examined in the VD laboratory of the Department for Dermatology of the University Hospital of Zurich. 86 isolates were penicillinase producing Neisseria gonorrhoeae strains (PPNG). The MIC ranges for penicillin of the non-PPNG strains was 0.0035 to 16 mg/l, for tetracycline 0.03 to 8 mg/l, for spectinomycin 3.5 to 120 mg/l and for thiamphenicol 0.125 to 8 mg/l. 42 out of 86 PPNG strains (48.8%) had been imported from South-East Asia. Six patients (6.9%) with PPNG strains had been infected in Zurich. Plasmid patterns of all PPNG strains were determined. The 4.4 MD-plasmid ("Asian" type plasmid) was found in 68 of 86 strains. The 3.2 MD-plasmid ("African" type plasmid) in 8 of 86 and the 24.6 MD-plasmid (transfer plasmid) in 56 PPNG strains respectively. The range of the MIC for penicillin of the PPNG strains was 1-16 mg/l, for tetracycline 0.25-8 mg/l, for spectinomycin 7-30 mg/l and for thiamphenicol 0.125-2 mg/l. The frequency of PPNG strains increased from 1.7% in 1981 to 6.7% in 1985.
1981年至1985年期间，苏黎世大学医院皮肤科性病实验室分离并检测了2232株淋病奈瑟菌。86株分离株为产青霉素酶淋病奈瑟菌（PPNG）菌株。非PPNG菌株对青霉素的最低抑菌浓度（MIC）范围为0.0035至16mg/l，对四环素为0.03至8mg/l，对壮观霉素为3.5至120mg/l，对甲砜霉素为0.125至8mg/l。86株PPNG菌株中有42株（48.8%）是从东南亚传入的。6例（6.9%）感染PPNG菌株的患者是在苏黎世感染的。测定了所有PPNG菌株的质粒图谱。在86株菌株中的68株中发现了4.4 MD质粒（“亚洲”型质粒）。86株中的8株发现了3.2 MD质粒（“非洲”型质粒），56株PPNG菌株中分别发现了24.6 MD质粒（转移质粒）。PPNG菌株对青霉素的MIC范围为1至16mg/l，对四环素为0.25至8mg/l，对壮观霉素为7至30mg/l，对甲砜霉素为0.125至2mg/l。PPNG菌株的频率从1981年的1.7%增加到1985年的6.7%。
