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人类用于有机合成的酶。

Human Enzymes for Organic Synthesis.

机构信息

Institute for Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010, Graz, Austria.

acib GmbH, Petersgasse 14, 8010, Graz, Austria.

出版信息

Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13406-13423. doi: 10.1002/anie.201800678. Epub 2018 Sep 11.

DOI:10.1002/anie.201800678
PMID:29600541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6334177/
Abstract

Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.

摘要

人类酶在各个领域都得到了广泛的研究。人体内发生的反应数量庞大，潜在的合成催化剂数量也很多。在此，我们重点介绍了在药物和外源性物质代谢过程中催化化学反应的人类酶的应用。其中一些反应已经在制备规模上进行了探索。人类酶的主要应用领域是目前的药物开发，用于合成药物代谢物。

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