Chen Linjun, Zhu Lihua, Cai Changming, Yan Guijun, Sun Haixiang
a Reproductive Medical Center , Drum Tower Hospital, Nanjing University Medical College , Nanjing , People's Republic of China.
Syst Biol Reprod Med. 2018 Aug;64(4):240-245. doi: 10.1080/19396368.2018.1453563. Epub 2018 Mar 30.
This retrospective study evaluated the association between frozen donor sperm used for intrauterine insemination and clinical and neonatal outcomes, including 304 singleton pregnancies resulting from artificial insemination by the husband (AIH) and 173 singleton pregnancies resulting from artificial insemination by a donor (AID). The clinical outcomes for AID showed no increased risk of abortion, ectopic pregnancy or pregnancy complications compared to those for AIH. There were no differences in gender, gestational age or prematurity of live births between the two groups. However, the birthweight of live births from AID was significantly higher than that from AIH. Moreover, the AID group exhibited no increased risk of stillbirths or fetal defects compared to the AIH group. These results indicate that frozen donor sperm did not increase the occurrence of adverse clinical and neonatal outcomes when compared to sperm from the husband.
AID: artificial insemination by a donor; AIH: artificial insemination by the husband; ART: assisted reproduction technology; FET: frozen embryo transfer; IVF: in vitro fertilization; ICSI: intracytoplasmic sperm injection; IUI: intrauterine insemination; LBW: low birth weight.
这项回顾性研究评估了用于宫内人工授精的冷冻供体精子与临床及新生儿结局之间的关联，其中包括304例丈夫精液人工授精（AIH）后的单胎妊娠和173例供体精液人工授精（AID）后的单胎妊娠。与AIH相比，AID的临床结局显示流产、异位妊娠或妊娠并发症风险并未增加。两组活产儿的性别、孕周或早产情况无差异。然而，AID活产儿的出生体重显著高于AIH活产儿。此外，与AIH组相比，AID组死产或胎儿缺陷风险并未增加。这些结果表明，与丈夫的精子相比，冷冻供体精子并未增加不良临床及新生儿结局的发生率。
AID：供体精液人工授精；AIH：丈夫精液人工授精；ART：辅助生殖技术；FET：冷冻胚胎移植；IVF：体外受精；ICSI：卵胞浆内单精子注射；IUI：宫内人工授精；LBW：低出生体重
