Department of Diagnostic Radiology and Nuclear Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
J Magn Reson Imaging. 2018 Oct;48(4):1059-1068. doi: 10.1002/jmri.26018. Epub 2018 Mar 30.
Although the prognosis of colorectal carcinoma (CRC) patients depends on the histologic grade (HG) and lymph node metastasis (LNM), accurate preoperative assessment of these prognostic factors is often difficult.
To assess the HG and extent of LNM by q-space imaging (QSI) for preoperative diagnosis of CRC.
Prospective.
A total of 20 colorectal tissue samples containing adenocarcinomas and resected lymph nodes (LNs).
FIELD STRENGTH/SEQUENCE: QSI was performed with a 3T MRI system using a diffusion-weighted echo-planar imaging sequence: repetition time, 10,000 msec; echo time, 216 or 210 msec; field of view, 113 × 73.45 mm; matrix, 120 × 78; section thickness, 4 mm; and 11 b values ranging from 0 to 9000 s/mm .
The mean displacement (MDP; μm), zero-displacement probability (ZDP; arbitrary unit [a.u.]), kurtosis (K; a.u.), and apparent diffusion coefficient (ADC) were analyzed by two observers and compared with histopathologic findings.
Spearman's rank correlation coefficient, Mann-Whitney U-test, and ROC curve analyses.
For all 20 carcinomas, the MDP, ZDP, K, and ADC were 8.87 ± 0.37 μm, 82.0 ± 6.2 a.u., 74.3 ± 3.0 a.u., and 0.219 ± 0.040 × 10 mm /s, respectively. The MDP (r = -0.768; P < 0.001), ZDP (r = 0.768; P < 0.001), and K (r = 0.785; P < 0.001) were significantly correlated with the HG of CRC, but not the ADC (r = 0.088; P = 0.712). There were also significant differences in the MDP, ZDP, and K between metastatic and nonmetastatic LNs (all, P < 0.001), but not the ADC (P = 0.082). In the HG of CRC and LNM, the area under the curve was significantly greater for MDP, ZDP, and K than for ADC.
QSI provides useful diagnostic information to assess the HG and extent of LNM in CRC.
1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1059-1068.
尽管结直肠癌（CRC）患者的预后取决于组织学分级（HG）和淋巴结转移（LNM），但通常难以准确术前评估这些预后因素。
通过 q-space 成像（QSI）评估 CRC 的 HG 和 LNM 程度，用于 CRC 的术前诊断。
前瞻性。
共 20 例包含腺癌和切除淋巴结（LNs）的结直肠组织样本。
磁场强度/序列：使用 3T MRI 系统进行 QSI，采用扩散加权回波平面成像序列：重复时间，10000 msec；回波时间，216 或 210 msec；视野，113×73.45 mm；矩阵，120×78；层厚，4 mm；11 个 b 值范围从 0 到 9000 s/mm 。
由两位观察者分析平均位移（MDP；μm）、零位移概率（ZDP；任意单位[a.u.]）、峰度（K；a.u.）和表观扩散系数（ADC），并与组织病理学结果进行比较。
Spearman 秩相关系数、Mann-Whitney U 检验和 ROC 曲线分析。
对于所有 20 例癌，MDP、ZDP、K 和 ADC 分别为 8.87±0.37 μm、82.0±6.2 a.u.、74.3±3.0 a.u.和 0.219±0.040×10 mm /s。MDP（r=-0.768；P<0.001）、ZDP（r=-0.768；P<0.001）和 K（r=-0.785；P<0.001）与 CRC 的 HG 显著相关，但 ADC 无相关性（r=0.088；P=0.712）。转移性和非转移性 LNs 之间的 MDP、ZDP 和 K 也有显著差异（均 P<0.001），但 ADC 无差异（P=0.082）。在 CRC 的 HG 和 LNM 中，MDP、ZDP 和 K 的曲线下面积明显大于 ADC。
QSI 提供了有用的诊断信息，可用于评估 CRC 的 HG 和 LNM 程度。
1 技术功效：2 阶段。J. Magn. Reson. Imaging 2018；48：1059-1068.
