Dubaniewicz Anna
Department of Pulmonology, Medical University of Gdansk, Poland.
Pol Merkur Lekarski. 2018 Mar 27;44(261):91-96.
In the light of modified the Matzinger's model of immune response, human heat shock proteins (hsp) as main 'danger signals' (tissue damage-associated molecular patterns-DAMPs) or/and microbial hsp as pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors (PRR), may induce sarcoid granuloma by both infectious and non-infectious factors in genetically different predisposed host.
根据对Matzinger免疫反应模型的修正，人类热休克蛋白（hsp）作为主要的“危险信号”（组织损伤相关分子模式——DAMPs）或/和微生物hsp作为被模式识别受体（PRR）识别的病原体相关分子模式（PAMPs），可能在遗传上不同的易感宿主中由感染性和非感染性因素诱导形成结节病肉芽肿。
